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Analyzing peptides and proteins by mass spectrometry: principles and applications in proteomics
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Abstract
The study of proteins has been a key element in biomedicine and biotechnology because of their important role in cell functions or enzymatic activity. Cells are the basic unit of living organisms, which are governed by a vast range of chemical reactions. These chemical reactions must be highly regulated
in order to achieve homeostasis. Proteins are polymeric molecules that have
taken on the evolutionary process the role, along with other factors, of control
these chemical reactions. Learning how proteins interact and control their up and
down regulations can teach us how living cells regulate their functions, as well as
the cause of certain anomalies that occur in different diseases where proteins are
involved. Mass spectrometry (MS) is an analytical widely used technique to study
the protein content inside the cells as a biomarker point, which describes
dysfunctions in diseases and increases knowledge of how proteins are working.
All the methodologies involved in these descriptions are integrated in the field
called Proteomics.
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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32166
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FIDALGO, María José, et al. Analyzing peptides and proteins by mass spectrometry: principles and applications in proteomics. Capítol del llibre: Handbook of instrumental techniques for materials. chemical and biosciences research. Vol. Universitat de Barcelona, num. Barcelona, pags. Part III. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/32062