Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/177033
FLRTing Neurons in Cortical Migration During Cerebral Cortex Development
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
During development, two coordinated events shape the morphology of the mammalian cerebral cortex, leading to the cortex's columnar and layered structure: the proliferation of neuronal progenitors and cortical migration. Pyramidal neurons originating from germinal zones migrate along radial glial fibers to their final position in the cortical plate by both radial migration and tangential dispersion. These processes rely on the delicate balance of intercellular adhesive and repulsive signaling that takes place between neurons interacting with different substrates and guidance cues. Here, we focus on the function of the cell adhesion molecules fibronectin leucine-rich repeat transmembrane proteins (FLRTs) in regulating both the radial migration of neurons, as well as their tangential spread, and the impact these processes have on cortex morphogenesis. In combining structural and functional analysis, recent studies have begun to reveal how FLRT-mediated responses are precisely tuned - from forming different protein complexes to modulate either cell adhesion or repulsion in neurons. These approaches provide a deeper understanding of the context-dependent interactions of FLRTs with multiple receptors involved in axon guidance and synapse formation that contribute to finely regulated neuronal migration.
Related resource
Subject (English)
Citation
Citation
PEREGRINA CABREDO, Claudia and TORO RUIZ, Daniel del. FLRTing Neurons in Cortical Migration During Cerebral Cortex Development. Frontiers In Cell And Developmental Biology. 2020. Vol. 8, num. 578506. ISSN 2296-634X. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/177033