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2014-03

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127864

DNA gel particles: An overview

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Recurs relacionat

https://doi.org/10.1016/j.cis.2013.09.002

Resum

A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying the chemical structure of the cationic cosolute, determines the spatial homogeneity of the gelation process, creating DNA reservoir devices and DNA matrix devices that can be designed to release either single- (ssDNA) or double-stranded (dsDNA). This review covers recent developments on the topic of DNA gel particles formed in water-water emulsion-type interfaces. The degree of DNA entrapment, particle morphology, swelling/dissolution behaviour and DNA release responses are discussed as a function of the nature of the cationic agent used. On the basis of designing DNA gel particles for therapeutic purposes, recent studies on the determination of the surface hydrophobicity, the haemolytic and the cytotoxic assessments of the obtained DNA gel particles have been also reported.

Matèries

ADN, Agents tensioactius, Materials nanoestructurats, Polímers, Sistemes d'alliberament de medicaments, Nanopartícules, Col·loides en medicina

Matèries (anglès)

DNA, Surface active agents, Nanostructured materials, Polymers, Drug delivery systems, Nanoparticles, Colloids in medicine

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Col·leccions

Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

MORÁN BADENAS, María del carmen, VINARDELL MARTÍNEZ-HIDALGO, Ma. pilar, INFANTE MARTÍNEZ-PARDO, Ma. rosa, MIGUEL, M. graça, LINDMAN, Björn. DNA gel particles: An overview. _Advances in Colloid and Interface Science_. 2014. Vol. 205, núm. 240-256. [consulta: 14 de gener de 2026]. ISSN: 0001-8686. [Disponible a: https://hdl.handle.net/2445/127864]

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