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MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
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The continuous flow of new research articles on MDR-TB
diagnosis, treatment, prevention and rehabilitation requires
frequent update of existing guidelines. This review is aimed at
providing clinicians and public health staff with an updated and
easy-to-consult document arising from consensus of Global
Tuberculosis Network (GTN) experts. The core published documents
and guidelines have been reviewed including the recently
published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA
guidelines. After a rapid review of epidemiology and risk
factors, the clinical priorities on MDR-TB diagnosis (including
whole genome sequencing and drug-susceptibility testing
interpretations) and treatment (treatment design and management,
TB in children) are discussed. Furthermore, the review
comprehensively describes the latest information on contact
tracing and LTBI management in MDR-TB contacts, while providing
guidance on post-treatment functional evaluation and
rehabilitation of TB sequelae, infection control and other
public health priorities.
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MIGLIORI, Giovanni Battista, et al. MDR/XDR-TB management of patients and contacts: challenges
facing the new decade. The 2020 clinical update by the Global
Tuberculosis Network. International Journal of Infectious Diseases. 2020. Vol. 92, num. S15-S25. ISSN 1201-9712. [consulted: 22 of June of 2026]. Available at: https://hdl.handle.net/2445/154277