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2015-05-28

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cc-by (c) Hew, Meilyn et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/105456

The possible future roles for IPSC-Derived therapy for Autoimmune Diseases.

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https://doi.org/10.3390/jcm4061193

Abstract

The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date.

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Cèl·lules mare, Autoimmunitat, Teràpia cel·lular

Subject (English)

Stem cells, Autoimmunity, Cellular therapy

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Articles publicats en revistes (Biomedicina)

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HEW, Meilyn, et al. The possible future roles for IPSC-Derived therapy for Autoimmune Diseases. Journal of Clinical Medicine. 2015. Vol. 4, num. 6, pags. 1193-1206. ISSN 2077-0383. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/105456

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