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Fitxers

679195.pdf (2.55 MB)

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2017-11-27

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cc-by (c) Burguera D. et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121070

Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

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Recurs relacionat

https://doi.org/10.1038/s41467-017-01961-y

Resum

Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co- opted into the development of many novel traits in vertebrates.

Matèries

Genètica molecular, Morfogènesi, Regulació genètica, Embriologia

Matèries (anglès)

Molecular genetics, Morphogenesis, Genetic regulation, Embryology

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

BURGUERA HERNÁNDEZ, Demian, MARQUEZ, Yamile, RACIOPPI, Claudia, PERMANYER I UGARTEMENDIA, Jon, TORRES-MÉNDEZ, Antonio, ESPOSITO, Rosaria, ALBUIXECH CRESPO, Beatriz, FANLO, Lucía, D'AGOSTINO, Ylenia, GOHR, Andre, NAVAS PÉREZ, Enrique, RIESGO GIL, Ana, CUOMO, Claudia, BENVENUTO, Giovanna, CHRISTIAEN, Lionel a., MARTÍ, Elisa, D'ANIELLO, Salvatore, SPAGNUOLO, Antonietta, RISTORATORE, Filomena, ARNONE, Maria ina, GARCIA FERNÁNDEZ, Jordi, IRIMIA MARTÍNEZ, Manuel. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. _Nature Communications_. 2017. Vol. 8, núm. 1, pàgs. 1799. [consulta: 7 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/121070]

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