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Published version

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2016-06-23

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cc-by-nc-nd (c) Amat Tusón, Mercedes et al., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/104863

Synthesis of fluvirucins and their aglycons, the fluvirucinins

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https://doi.org/10.1055/s-0035-1561469

Abstract

Fluvirucins are bioactive macrolactam glycosides isolated from actinomycetes. This review gives an overview of this family of natural products, covering isolation, biological activities, biosynthesis, and total synthesis. The synthesis of fluvirucins and their aglycons, the fluvirucinins, is presented, paying special attention to the synthetic strategy and stereochemical aspects. 1 Introduction 2 Isolation, Biological Activity, and Biosynthesis 3 Synthetic Approaches 3.1 Closure of the 14-Membered Ring by Ring-Closing Metathesis 3.2 Closure of the 14-Membered Ring by Macrolactamization 3.3 Construction of the 14-Membered Ring by Aza-Claisen Ring Expansion 4 Conclusion

Subject

Lactames, Glucòsids

Subject (English)

Lactams, Glucosides

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

AMAT TUSÓN, Mercedes, et al. Synthesis of fluvirucins and their aglycons, the fluvirucinins. Synthesis. 2016. Vol. 48, num. 17, pags. 2705-2720. ISSN 0328-1205. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/104863

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