Carregant...
Tipus de document
Treball de fi de grauData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175846
A bibliographic review on capuramycin, a nucleosidic natural product with antibiotic properties
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Antibacterial resistance has become an urgent issue for human being and animal’s health. Among these resistant bacteria stand out important pathogens such as M. tuberculosis, M. smegmatis and S. pneumoniae. Notably, these pathogens were inhibited by natural uridine antibiotics such as capuramycin, a compound first isolated from Streptomyces griseus. This type of antibiotics acts by inhibiting MraY, an enzyme involved in the biosynthesis of peptydoglican component of the bacteria cell wall, but showed low antibacterial activity. Consequently, capuramycin analogues have been prepared by organic synthesis and biosynthesis to allow structure-activity studies as a prior step towards the development of new antibacterial drugs.
In this context, this present TFG report contains a bibliographic review on capuramycin, with a particular emphasis on the synthetic routes of the compound and its derivatives, the elucidation of the biosynthetic pathways and their applications, and studies of structure-antibacterial activity.
Descripció
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2020, Tutor: Jordi Robles Brau
Matèries (anglès)
Citació
Col·leccions
Citació
RUIZ FONT, Elisabet. A bibliographic review on capuramycin, a nucleosidic natural product with antibiotic properties. [consulta: 6 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/175846]