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Rebollo-Calderón-Beatriz.pdf (1.11 MB)

Document type

Master thesis

Publication date

2018-11

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cc-by-nc-nd (c) Rebollo, 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/126206

The role of cellular contractility in topography sensing on soft nanoporous polyacrylamide hydrogels

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Abstract

Extracellular matrix physical characteristics have been shown to play an important role in cellular processes such as adhesion, migration, proliferation and differentiation. Of high importance are the stiffness and the topography of the extracellular matrix, which are believed to activate shared signalling pathways to cause a cellular response. In this work, we use polyacrylamide nanoporous hydrogels of different stiffness, both with and without microtopographical structures to see if these physical cues are truly sensed by the same mechanism, and an inhibitor of ROCK I to determine the role of cell contractility in the sensing of topography and stiffness

Description

Màster en Nanociència i Nanotecnologia, Facultat de Física, Universitat de Barcelona, Curs: 2017-2018. Tutor: Jordi Comelles

Subject

Ultraestructura (Biologia), Matriu extracel·lular, Treballs de fi de màster

Subject (English)

Ultrastructure (Biology), Extracellular matrix, Master's theses

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Màster Oficial - Nanociència i Nanotecnologia

Citation

REBOLLO CALDERÓN, Beatriz. The role of cellular contractility in topography sensing on soft nanoporous polyacrylamide hydrogels. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/126206

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