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2196.pdf (5.28 MB)

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2014-12-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/117483

A chemo-centric view of human health and disease

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http://dx.doi.org/10.1038/ncomms6676

Resum

Efforts to compile the phenotypic effects of drugs and environmental chemicals offer the opportunity to adopt a chemo-centric view of human health that does not require detailed mechanistic information. Here we consider thousands of chemicals and analyse the relationship of their structures with adverse and therapeutic responses. Our study includes molecules related to the aetiology of 934 health-threatening conditions and used to treat 835 diseases. We first identify chemical moieties that could be independently associated with each phenotypic effect. Using these fragments, we build accurate predictors for approximately 400 clinical phenotypes, finding many privileged and liable structures. Finally, we connect two diseases if they relate to similar chemical structures. The resulting networks of human conditions are able to predict disease comorbidities, as well as identifying potential drug side effects and opportunities for drug repositioning, and show a remarkable coincidence with clinical observations.

Matèries

Investigació mèdica, Salut pública

Matèries (anglès)

Medicine research, Public health

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Publicacions de projectes de recerca finançats per la UE

Citació

DURAN FRIGOLA, Miquel, ROSSELL, David and ALOY, Patrick. A chemo-centric view of human health and disease. Nature Communications. 2014. Vol. 5, num. 5676. ISSN 2041-1723. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/117483

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