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Accepted version

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2022-06-01

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cc-by-nc-nd (c) Current Opinion, 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218668

HATs meet structural biology

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https://doi.org/10.1016/j.sbi.2022.102389

Abstract

Heteromeric amino acid transporters (HATs) are one of the ten types of amino acid transporters present in the human body. Growing interest in the pathophysiological role of this group of transporters in rare and complex diseases and cancer has brought about the recent resolution of various structures of human HATs and bacterial homologues at atomic level. This knowledge sheds light on the mechanisms of transport used by these molecules. Here, we discuss the molecular bases underlying substrate specificity, binding asymmetry, and the impact of disease-causing mutations on transporter biogenesis and function.

Subject

Transport biològic, Biologia molecular, Aminoàcids

Subject (English)

Biological transport, Molecular biology, Amino acids

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Articles publicats en revistes (Ciències Fisiològiques)

Citation

RULLO TUBAU, Josep, et al. HATs meet structural biology. Current Opinion in Structural Biology. 2022. Vol. 74. ISSN 0959-440X. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/218668

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