Files
Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/49273
High-resolution mass spectrometry applied to the study of metabolome modifications in various chicken tissues after amoxicillin administration
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
The performance of high resolution accurate mass spectrometry (HRMS) operating in full scan MS mode was investigated for the quantitative determination of amoxicillin (AMX) as well as qualitative analysis of metabolomic profiles in tissues of medicated chickens. The metabolomic approach was exploited to compile analytical information on changes in the metabolome of muscle, kidney and liver from chickens subjected to a pharmacological program with AMX. Data consisting of m/z features taken throughout the entire chromatogram were extracted and filtered to be treated by Principal Component Analysis. As a result, it was found that medicated and non-treated animals were clearly clustered in distinct groups. Besides, the multivariate analysis revealed some relevant mass features contributing to this separation. In this context, recognizing those potential markers of each chicken class was a priority research for both metabolite identification and, obviously, evaluation of food quality and health effects associated to food consumption.
Related resource
Subject (English)
Citation
Citation
HERMO OUTEIRAL, Ma. del Pilar, et al. High-resolution mass spectrometry applied to the study of metabolome modifications in various chicken tissues after amoxicillin administration. Food Chemistry. 2014. Vol. 153, num. 405-413. ISSN 0308-8146. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/49273