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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193282
The Modular architecture of metallothioneins facilitates domain rearrangements and contributes to their evolvability in metal-accumulating mollusks.
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Protein domains are independent structural and functional modules that can rearrange to create new proteins. While the evolution of multidomain proteins through the shuffling of different preexisting domains has been well documented, the evolution of domain repeat proteins and the origin of new domains are less understood. Metallothioneins (MTs) provide a good case study considering that they consist of metal-binding domain repeats, some of them with a likely de novo origin. In mollusks, for instance, most MTs are bidomain proteins that arose by lineage-specific rearrangements between six putative domains: α, β1, β2, β3, γ and δ. Some domains have been characterized in bivalves and gastropods, but nothing is known about the MTs and their domains of other Mollusca classes. To fill this gap, we investigated the metal-binding features of NpoMT1 of Nautilus pompilius (Cephalopoda class) and FcaMT1 of Falcidens caudatus (Caudofoveata class). Interestingly, whereas NpoMT1 consists of α and β1 domains and has a prototypical Cd2+ preference, FcaMT1 has a singular preference for Zn2+ ions and a distinct domain composition, including a new Caudofoveata-specific δ domain. Overall, our results suggest that the modular architecture of MTs has contributed to MT evolution during mollusk diversification, and exemplify how modularity increases MT evolvability.
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CALATAYUD, Sara, GARCIA-RISCO, Mario, PEDRINI-MARTHA, Veronika, NIEDERWANGER, Michael, DALLINGER, Reinhard, PALACIOS, Òscar, CAPDEVILA, Mercè, ALBALAT RODRÍGUEZ, Ricard. The Modular architecture of metallothioneins facilitates domain rearrangements and contributes to their evolvability in metal-accumulating mollusks.. _International Journal of Molecular Sciences_. 2022. Vol. 23, núm. 24, pàgs. 15824. [consulta: 25 de febrer de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/193282]