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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162031
Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats
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Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18 weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16.6 g/kg feed), proanthocyanidin-rich grape seed extract (0.8 g/kg feed) or both. A total of 39 microbial-derived metabolites and 16 conjugated metabolites were detected by HPLC-MS/MS either in urine or in the aqueous fraction of feces. An unexpected significant increase in many proanthocyanidin metabolites in urine and feces was observed in the group supplemented with ω-3 polyunsaturated fatty acids group as compared to the animals fed a standard diet, which contains a small amount of polyphenols. However, proanthocyanidin metabolites in rats given ω-3 polyunsaturated fatty acids and grape seed extract did not significantly differ from those in the group supplemented only with grape seed extract. It was concluded that ω-3 polyunsaturated fatty acids collaborate in the metabolism of polyphenols when present at low doses in the feed matrix, while the capacity of ω-3 polyunsaturated fatty acids to induce microbiota transformations when proanthocyanidins are present at high doses is not relevant compared to that of polyphenols themselves.
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MOLINAR TORIBIO, Eunice maría, RAMOS ROMERO, Sara, FUGUET I JORDÀ, Elisabet, TALTAVULL, Núria, MÉNDEZ, Lucía, ROMEU FERRAN, Marta, MEDINA, Isabel, TORRES, Josep lluís, PÉREZ-JIMÉNEZ, Jara. Influence of omega-3 PUFAs on the metabolism of proanthocyanidins in rats. _Food Research International_. 2017. Vol. 97, núm. 133-140. [consulta: 24 de gener de 2026]. ISSN: 0963-9969. [Disponible a: https://hdl.handle.net/2445/162031]