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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/170108
Advanced bioengineering technologies for preclinical research
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Current in vitro practices must overcome important challenges to compare favorably with human studies. The limited applicability of conventional in vitro assays and strategies can be explained by the fact that standard approaches do not enable recapitulation of the complexity of human tissues and physiological functions. To address this challenge, novel bioengineering tools, techniques and technologies are rapidly emerging to advance current fundamental knowledge and innovate in vitro practices. For example, organs-on-a-chip have recently appeared as a small-scale solution to overcome the transability, financial and ethical concerns associated with animal studies in drug discovery and development. In parallel, biomimetic interfaces are increasingly recapitulating 3D structures with tissue-like dynamic properties to allow in-depth investigation of disease mechanisms. This review aims at highlighting current bioengineering approaches poised to address the shortcomings of conventional in vitro research practices towards the generation of more effective solutions for improving human health.
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MARTÍNEZ FRAIZ, Elena, ST-PIERRE, Jean-Philippe and VARIOLA, Fabio. Advanced bioengineering technologies for preclinical research. Advances in Physics: X. 2019. Vol. 4, num. 1, pags. 423-450. ISSN 2374-6149. [consulted: 9 of October of 2026]. Available at: https://hdl.handle.net/2445/170108