The polymerization of Aeromonas hydrophila AH-3 O-antigen LPS: concerted action of WecP and Wzy

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dc.contributor.authorMerino Montero, Susana
dc.contributor.authorGonzalez, Victor
dc.contributor.authorTomàs Magaña, Juan
dc.date.accessioned2016-12-01T15:36:43Z
dc.date.available2016-12-01T15:36:43Z
dc.date.issued2015-07-10
dc.date.updated2016-12-01T15:36:48Z
dc.description.abstractThe repeat units of heteropolymeric O antigen are synthesized at the cytosolic side of the inner bacterial membrane via the Wzx/Wzy-dependent assembly pathway. After being translocated across the membrane by Wzx, each repeat unit is polymerized by Wzy to form a glycan chain. In this study, we demonstrate the need of the corresponding enzyme trans- ferring the initial HexNAc to undecaprenol phosphate (lipid carrier), together with the corre- sponding O-antigen polymerase (Wzy), to produce the Aeromonas hydrophila O:34- antigen. We suggest, the concerted action of WecA or P enzyme (UDP-HexNAc: polypre- nol-P HexNAc-1-P transferase) and Wzy is involved in the mechanism responsible for the A . hydrophila O-antigen polymerization.
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec653853
dc.identifier.issn1932-6203
dc.identifier.pmid26161781
dc.identifier.urihttps://hdl.handle.net/2445/104357
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131905
dc.relation.ispartofPLoS One, 2015, vol. 10, num. 7, p. e0131905
dc.relation.urihttps://doi.org/10.1371/journal.pone.0131905
dc.rightscc-by (c) Merino Montero, Susana et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject.classificationBacteriòfags
dc.subject.classificationTransferases
dc.subject.classificationPolimerització
dc.subject.otherBacteriophages
dc.subject.otherTransferases
dc.subject.otherPolymerization
dc.titleThe polymerization of Aeromonas hydrophila AH-3 O-antigen LPS: concerted action of WecP and Wzy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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