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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220716
Total Synthesis of the Myrioneuron Alkaloid (–)-Schoberine B and Its Enantiomer (+)-Schoberine B
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A dynamic kinetic asymmetric transformation, involving the generation of four stereogenic centers with a well-defined configuration, occurs in the cyclocondensation of diastereomeric mixtures of 2-oxocyclohexanepropionic acid racemates with (1S,2R)-cis-aminoindanol: two major tetracyclic lactams, that differ in the configuration of the four stereocenters on the decahydroquinoline moiety were obtained. From the above lactams, the removal of the chiral auxiliary, the introduction of a 2-piperidone ring, and the closure of the diazine ring complete the first enantioselective total synthesis of the Myrioneuron alkaloid (–)-schoberine B and its enantiomer (+)-schoberine B.
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CALBÓ ZABALA, Arnau, et al. Total Synthesis of the Myrioneuron Alkaloid (–)-Schoberine B and Its Enantiomer (+)-Schoberine B. Advanced Synthesis & Catalysis. 2023. Vol. 365. ISSN 1615-4150. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/220716