Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/119747
New perspectives on corpora amylacea in the human brain
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Corpora amylacea are structures of unknown origin and function that appear with age in human brains and are profuse in selected brain areas in several neurodegenerative conditions. They are constituted of glucose polymers and may contain waste elements derived from different cell types. As we previously found on particular polyglucosan bodies in mouse brain, we report here that corpora amylacea present some neo-epitopes that can be recognized by natural antibodies, a certain kind of antibodies that are involved in tissue homeostasis. We hypothesize that corpora amylacea, and probably some other polyglucosan bodies, are waste containers in which deleterious or residual products are isolated to be later eliminated through the action of the innate immune system. In any case, the presence of neo-epitopes on these structures and the existence of natural antibodies directed against them could become a new focal point for the study of both age-related and degenerative brain processes.
Matèries (anglès)
Citació
Citació
AUGÉ MARÍ, Elisabet, CABEZÓN RODRÍGUEZ, Itsaso, PELEGRÍ I GABALDÀ, Carme, VILAPLANA I HORTENSI, Jordi. New perspectives on corpora amylacea in the human brain. _Scientific Reports_. 2017. Vol. 7. [consulta: 22 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/119747]