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Isocyanides as Acceptor Groups in MHAT Reactions with Unactivated Alkenes

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dc.contributor.authorPuig Bosch, Jordi
dc.contributor.authorBonjoch, Josep
dc.contributor.authorBradshaw, Ben
dc.date.accessioned2025-01-16T19:26:47Z
dc.date.available2025-01-16T19:26:47Z
dc.date.issued2023-08-30
dc.date.updated2025-01-16T19:26:47Z
dc.description.abstractThe use of isocyanides as acceptor groups in metal–hydride hydrogen atom transfer (MHAT) coupling reactions with nonactivated alkenes to form heterocycles is described. Monosubstituted alkenes couple and cyclize directly, whereas more substituted alkenes proceed via a two-step, one-pot procedure involving MHAT reductive cyclization followed by a MHAT Minisci coupling upon the addition of acid. To highlight the utility of the methodology, a diverse variety of substituted heterocycles such as phenanthridines, indoles, and isoquinolines were prepared.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec745439
dc.identifier.issn1523-7060
dc.identifier.urihttps://hdl.handle.net/2445/217580
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1021/acs.orglett.3c02358
dc.relation.ispartofOrganic Letters, 2023, vol. 25, num.35, p. 6539-6543
dc.relation.urihttps://doi.org/10.1021/acs.orglett.3c02358
dc.rightscc by (c) Jordi Puig, et al., 2023
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationHidrogen
dc.subject.classificationAlquens
dc.subject.classificationÀtoms
dc.subject.otherHydrogen
dc.subject.otherAlkenes
dc.subject.otherAtoms
dc.titleIsocyanides as Acceptor Groups in MHAT Reactions with Unactivated Alkenes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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