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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/151350
Nucleotide excision repair genes shaping embryonic development
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Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental genotoxins, most notably ultraviolet radiation. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy are three human disorders caused by inherited defects in NER. The symptoms and severity of these diseases vary dramatically, ranging from profound developmental delay to cancer predisposition and accelerated ageing. All three syndromes include developmental abnormalities, indicating an important role for optimal transcription and for NER in protecting against spontaneous DNA damage during embryonic development. Here, we review the current knowledge on genes that function in NER that also affect embryonic development, in particular the development of a fully functional nervous system.
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ARAÚJO, Sofia J. and KURAOKA, Isao. Nucleotide excision repair genes shaping embryonic development. Open Biology. 2019. Vol. 9, num. 10, pags. 190166. ISSN 2046-2441. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/151350