Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/181570
Fixed Regimen Treatment in Unselected Naive Patients Cohort with Neovascular Age-Related Macular Degeneration
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The current treatment of neovascular age-related macular degeneration (nAMD) generates an excessive care pressure in the public health system. The search for a satisfactory treatment regimen, whose anatomical and functional stability may be achieved, is a challenge and a goal to be reached. We analyzed the outcomes in a patient cohort under fixed regimen treatment with intravitreal aflibercept (IVA). A retrospective study, with at least 1-year follow-up, in consecutive treated unselected naïve patients was carried out. Standard protocol was performed and evaluated at baseline, month 4 (after loading dose, LD), and month 12 (after fixed bimonthly regimen). One hundred six patients (123 eyes) aged 80.3 ± 7.7 years were included, receiving 6.8 ± 0.7 IVA. Visual acuity gain after LD was 5.5 ± 12.0 letters (). At month 12, 23 eyes (18.7%) gained ≥15 letters and 58 (47.1%) had best-corrected visual acuity ≥20/40 (70 letters). The improvement in visual acuity was lower in patients with polypoidal choroidal vasculopathy (+4.9 ± 18.1 letters; p = 0.2544) and somewhat higher in patients with retinal angiomatous proliferation (+5.4 ± 12.3 letters; ). Dry macula was present in only 9.8% of cohort at baseline vs. 69.7% at month 12 (). Atrophy was the most observed complication and related to the elderly patients. The average of follow-up visits was 3 ± 0.5. Functional and anatomical improvement were observed with IVA in a fixed bimonthly regimen treatment after LD, with results maintained up to one year with a good compliance. The fixed bimonthly regimen optimized patient management and logistic issues.
Subject
Subject (English)
Citation
Citation
CASAROLI MARANO, Ricardo Pedro, et al. Fixed Regimen Treatment in Unselected Naive Patients Cohort with Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology. 2020. Vol. 2020, num. 8848336. ISSN 2090-004X. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/181570