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2021-09-27

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cc-by-nc-nd (c) Vilaseca González, Isabel et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/195211

Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments

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https://doi.org/10.1002/hed.26878

Resum

To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Background: To evaluate the importance of larynx compartments in the prognosis of T3-T4a laryngeal cancer treated with transoral laser microsurgery. Methods: Two hundred and two consecutive pT3-T4a larynx carcinomas. Pre-epiglottic space involvement, anterior and posterior paraglottic space (PGS) involvement, vocal cord, and arytenoid mobility were determined. Local control with laser (LC), overall survival (OS), disease-specific survival (DSS), and laryngectomy-free survival (LFS) were evaluated. Results: The lowest LC was found in tumors with fixed arytenoid. In the multivariate analysis, positive margins (hazard ratio [HR] = 0.289 [0.085-0.979]) and anterior (HR = 0.278 [0.128-0.605]) and posterior (HR = 0.269 [0.115-0.630]) PGS invasion were independent factors of a reduced LC. Anterior (HR = 3.613 [1.537-8.495]) and posterior (HR = 5.195 [2.167-12.455]) PGS involvement were independent factors of total laryngectomy. Five-year OS, DSS, and LFS rates were 63.9%, 77.5%, and 77.5%, respectively. Patients with posterior PGS presented a reduced 5-year LFS. Conclusions: Tumor classification according to laryngeal compartmentalization depicts strong correlation with LC and LFS.

Matèries

Càncer de laringe, Microcirurgia, Làsers en cirurgia, Cartílag, Teixit connectiu

Matèries (anglès)

Larynx cancer, Microsurgery, Lasers in surgery, Cartilage, Connective tissue

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

VILASECA GONZÁLEZ, Isabel, AVILÉS JURADO, Francesc xavier, VALDUVIECO, Izaskun, BERENGUER, Joan, GRAU, Juan josé, BASTE, Neus, MUXÍ PRADAS, África, CASTILLO, Paola, LEHRER, Eduardo, JORDANA, Marta, RAMÍREZ RUIZ, Rosa delia, COSTA, José miguel, OLEAGA ZUFIRÍA, Laura, BERNAL SPREKELSEN, Manuel. Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. _Head & Neck. Journal for the Sciences and Specialties of the Head and Neck_. 2021. Vol. 43, núm. 12, pàgs. 3832-3842. [consulta: 23 de gener de 2026]. ISSN: 1043-3074. [Disponible a: https://hdl.handle.net/2445/195211]

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