Miniatura

Fitxers

667961.pdf (1.21 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2016-10-14

Llicència de publicació

cc-by (c) Poroyko, Valeriy A. et al., 2016
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/111702

Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/srep35405

Resum

Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin resistance. These symptoms are known to be related to the host gut microbiota. Mice were exposed to SF for 4 weeks and then allowed to recover for 2 weeks. Taxonomic profiles of fecal microbiota were obtained prospectively, and conventionalization experiments were performed in germ-free mice. Adipose tissue insulin sensitivity and inflammation, as well as circulating measures of inflammation, were assayed. Effect of fecal water on colonic epithelial permeability was also examined. Chronic SF-induced increased food intake and reversible gut microbiota changes characterized by the preferential growth of highly fermentative members of Lachnospiraceae and Ruminococcaceae and a decrease of Lactobacillaceae families. These lead to systemic and visceral white adipose tissue inflammation in addition to altered insulin sensitivity in mice, most likely via enhanced colonic epithelium barrier disruption. Conventionalization of germ-free mice with SF-derived microbiota confirmed these findings. Thus, SF-induced metabolic alterations may be mediated, in part, by concurrent changes in gut microbiota, thereby opening the way for gut microbiome-targeted therapeutics aimed at reducing the major end-organ morbidities of chronic SF.

Matèries

Microbiologia mèdica, Microbiota, Obesitat, Trastorns del son

Matèries (anglès)

Medical microbiology, Microbiota, Obesity, Sleep disorders

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

POROYKO, Valeriy a., CARRERAS, Alba, KHALYFA, Abdelnaby, KHALYFA, Ahamed a., LEONE, Vanessa, PERIS, Eduard, ALMENDROS LÓPEZ, Isaac, GILELES-HILLEL, Alex, QIAO, Zhuanhong, HUBERT, Nathaniel, FARRÉ VENTURA, Ramon, CHANG, Eugene b., GOZAL, David. Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice.. _Scientific Reports_. 2016. Vol. 6, núm. 35405. [consulta: 20 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/111702]

Exportar metadades

JSON - METS

Compartir registre