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Sugar activation and glycosylation in Plasmodium
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Glycoconjugates are important mediators of host-pathogen
interactions and are usually very abundant in the surface of
many protozoan parasites. However, in the particular case of
Plasmodium species, previous works show that
glycosylphosphatidylinositol anchor modifications, and to an
unknown extent, a severely truncated N-glycosylation are the
only glycosylation processes taking place in the parasite.
Nevertheless, a detailed analysis of the parasite genome and the
recent identification of the sugar nucleotide precursors
biosynthesized by Plasmodium falciparum support a picture in
which several overlooked, albeit not very prominent
glycosylations may be occurring during the parasite life cycle.
In this work, the authors review recent developments in the
characterization of the biosynthesis of glycosylation precursors
in the parasite, focusing on the outline of the possible fates
of these precursors.
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COVA, Marta, et al. Sugar activation and glycosylation in Plasmodium. Malaria Journal. 2015. Vol. 14, num. 1, pags. 427. ISSN 1475-2875. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/69164