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2026-04-21

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cc-by (c) Alsina, R. et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229874

Cerebrospinal fluid sediments as a novel tool for potential biomarkers of neurodegenerative diseases

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Recurs relacionat

https://doi.org/10.3390/ijms27083692

Resum

Cerebrospinal fluid (CSF) biomarkers for neurodegenerative diseases have been extensively studied over the years. However, CSF samples are routinely centrifuged, and the resulting sediment or pellet is typically discarded to remove cellular debris and high-density particles. This standard practice raises a critical question: Could these discarded sediments harbour potential biomarkers? The aim of the present study is to demonstrate that CSF sediments contain specific brain-derived components and thus to substantiate the possible presence of biomarkers within these sediments. To this end, we analysed post-mortem CSF samples of one patient with neuropathologically confirmed Alzheimer’s disease (AD) and one patient with confirmed progressive supranuclear palsy (PSP). CSF pellets were studied using transmission and scanning electron microscopy techniques (TEM and SEM, respectively), along with compositional analysis through SEM combined with energy-dispersive X-ray spectroscopy (SEM-EDX), as well as immunofluorescence and histochemical analyses on semithin pellet sections. We observed that, among others, CSF pellets contain brain-derived structures such as wasteosomes and psammoma bodies. Furthermore, we also found disease-relevant proteins, including tau and Aβ42 in the AD sediment and tau in the PSP sediment. Although further studies are required, the study of CSF pellets could open new avenues for biomarker discovery in neurodegenerative diseases.

Matèries

Malalties neurodegeneratives, Malaltia d'Alzheimer, Líquid cefalorraquidi, Marcadors bioquímics

Matèries (anglès)

Neurodegenerative Diseases, Alzheimer's disease, Cerebrospinal fluid, Biochemical markers

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

ALSINA PLANELLES, Raquel, et al. Cerebrospinal fluid sediments as a novel tool for potential biomarkers of neurodegenerative diseases. International Journal of Molecular Sciences. 2026. Vol. 27, num. 8, pags. 3692. ISSN 1661-6596. [consulted: 25 of August of 2026]. Available at: https://hdl.handle.net/2445/229874

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