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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221871
Development of a Temperature- Controlled Environment for Neurovalidation
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This Final Degree Project presents the design and implementation of a temperature-controlled
chamber for studying the behavior of neural precursors under varying thermal conditions. The
chamber is intended as a core component within a broader initiative aimed at developing non-
invasive therapeutic devices for epilepsy treatment, particularly through ultrasound-induced brain
cooling.The device enables precise environmental temperature control. Its design integrates heating
elements, high-precision digital temperature sensors (TSIC 506F), and a closed-loop control system
managed by an Arduino Uno microcontroller, as well as a LabVIEW-based interface developed for
real-time data visualization and logging.
A methacrylate structure, supported by 3D-printed components, was selected for its transparency
and ease of fabrication after multiple versions were investigated to optimize chamber structure,
thermal distribution, and sensor integration. Both passive and forced-convection heating methods
were analyzed, with thermal validation conducted using infrared imaging. The chamber consistently
achieved the desired thermal range (36–37.5 °C), demonstrating spatial uniformity in controlled
experiments and representing an initial platform for analyzing the impact of temperature on neural
activity, contributing valuable data for the design of future brain-cooling neuromodulation devices.
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Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2024-2025. Tutor: Jordi Colomer ; Director: Neri Ruiz, Jordi Colomer
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MORA MENÉNDEZ, Guillermo. Development of a Temperature- Controlled Environment for Neurovalidation. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/221871