Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease

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dc.contributor.authorVázquez Carrera, Manuel
dc.date.accessioned2020-05-25T11:07:48Z
dc.date.available2020-05-25T11:07:48Z
dc.date.issued2016-03-20
dc.date.updated2020-05-25T11:07:49Z
dc.description.abstractInsulin resistance precedes dyslipidemia and type 2 diabetes mellitus (T2DM) development. Preclinical evidence suggests that peroxisome proliferator-activated receptor (PPAR) β/δ activators may prevent and treat obesity-induced insulin resistance and T2DM, while clinical trials highlight their potential utility in dyslipidemia. This review summarizes recent mechanistic insights into the antidiabetic effects of PPARβ/δ activators, including their anti-inflammatory actions, their ability to inhibit endoplasmic reticulum (ER) stress and hepatic lipogenesis, and to improve atherogenesis and insulin sensitivity, as well as their capacity to activate pathways that are also stimulated by exercise. Findings from clinical trials are also examined. Dissecting the effects of PPARβ/δ ligands on insulin sensitivity and atherogenesis may provide a basis for the development of therapies for the prevention and treatment of T2DM and cardiovascular disease (CVD).
dc.format.extent16 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec659283
dc.identifier.issn1043-2760
dc.identifier.pmid27005447
dc.identifier.urihttps://hdl.handle.net/2445/162264
dc.language.isoeng
dc.publisherElsevier Current Trends
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.tem.2016.02.008
dc.relation.ispartofTrends in Endocrinology and Metabolism, 2016, vol. 27, num. 5, p. 319-334
dc.relation.urihttps://doi.org/10.1016/j.tem.2016.02.008
dc.rightscc-by-nc-nd (c) Elsevier Current Trends, 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationDiabetis
dc.subject.classificationResistència a la insulina
dc.subject.classificationInflamació
dc.subject.otherDiabetes
dc.subject.otherInsulin resistance
dc.subject.otherInflammation
dc.titleUnraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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