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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/186494
A Galactooligosaccharide Product Decreases the Rotavirus Infection in Suckling Rats
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The leading cause of gastroenteritis among young children worldwide is the Group A rotaviruses (RV), which produce a wide range of symptoms, from a limited diarrhea to severe dehydration and even death. After an RV infection, immunity is not complete and less severe re-infections usually occur. These infections could be ameliorated by nutritional interventions with bioactive compounds, such as prebiotics. The aim of this research was to study the impact of a particular galactooligosaccharide (B-GOS) on the RV symptomatology and immune response during two consecutive infections. Lewis neonatal rats were inoculated with SA11 (first RV infection) on day 6 of life and with EDIM (second RV infection) on day 17 of life. B-GOS group was administered by oral gavage with a daily dose of B-GOS between days three to nine of life. Clinical and immunological variables were assessed during both infective processes. In the first infection, after the prebiotic intervention with B-GOS, a lower incidence, duration, and overall severity of the diarrhea (p < 0.05) was observed. In addition, it improved another severity indicator, the fecal weight output, during the diarrhea period (p < 0.05). The second RV infection failed in provoking diarrhea in the groups studied. The immune response during first infection with SA11 was not affected by B-GOS administration and had no impact on second infection, but the prebiotic intervention significantly increased IFN-γ and TNF-α intestinal production after the second infection (p < 0.05). In summary, B-GOS supplementation is able to reduce the incidence and severity of the RV-associated diarrhea and to influence the immune response against RV infections.
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MASSOT CLADERA, Malen, RIGO ADROVER, Maria del mar, HERRERO RODRÍGUEZ, Laura, FRANCH I MASFERRER, Àngels, CASTELL, Margarida, VULEVIC, Jelena, PÉREZ-CANO, Francisco j., RODRÍGUEZ LAGUNAS, María josé. A Galactooligosaccharide Product Decreases the Rotavirus Infection in Suckling Rats. _Cells_. 2022. [consulta: 27 de gener de 2026]. ISSN: 2073-4409. [Disponible a: https://hdl.handle.net/2445/186494]