Miniatura

Fitxers

885459.pdf (17.79 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2024-07-26

Llicència de publicació

cc-by (c) Pons-Tomàs, G. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219305

Deciphering the longevity and levels of SARS-CoV-2 Antibodies in children: A year-long study highlighting clinical phenotypes and age-related variations.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/pathogens13080622

Resum

Background: Identifying potential factors correlated with the sustained presence of antibodies in plasma may facilitate improved retrospective diagnoses and aid in the appraisal of pertinent vaccination strategies for various demographic groups. The main objective was to describe the persistence of anti-spike IgG one year after diagnosis in children and analyse its levels in relation to epidemiological and clinical variables. Methods: A prospective, longitudinal, observational study was conducted in a university reference hospital in the Metropolitan Region of Barcelona (Spain) (March 2020-May 2021). This study included patients under 18 years of age with SARS-CoV-2 infection (positive PCR or antigen tests for SARS-CoV-2). Clinical and serological follow-up one year after infection was performed. Results: We included 102 patients with a median age of 8.8 years. Anti-spike IgG was positive in 98/102 (96%) 12 months after the infection. There were higher anti-spike IgG levels were noted in patients younger than 2 years (p = 0.034) and those with pneumonia (p < 0.001). A positive and significant correlation was observed between C-reactive protein at diagnosis and anti-spike IgG titre one-year after diagnosis (p = 0.027). Conclusion: Anti-SARS-CoV-2 IgG antibodies were detected in almost all paediatric patients one year after infection. We also observed a positive correlation between virus-specific IgG antibody titres with SARS-CoV-2 clinical phenotype (pneumonia) and age (under 2 years old).

Matèries

SARS-CoV-2, Assistència hospitalària, Pediatria

Matèries (anglès)

SARS-CoV-2, Hospital care, Pediatrics

Citació

Col·leccions

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Citació

PONS TOMÀS, Gemma, PINO RAMÍREZ, Rosa mª, SOLER GARCÍA, Aleix, LAUNES MONTAÑA, Cristian, MARTÍNEZ DE ALBÉNIZ, Irene, RÍOS BARNÉS, María, MELÉ CASAS, Maria, HERNÁNDEZ GARCÍA, María, MONSONÍS, Manuel, GENÉ, Amadeu, FERNÁNDEZ DE SEVILLA ESTRACH, Mariona, GARCÍA GARCÍA, Juan josé, FORTUNY GUASCH, Claudia, FUMADÓ, Victoria. Deciphering the longevity and levels of SARS-CoV-2 Antibodies in children: A year-long study highlighting clinical phenotypes and age-related variations.. _Pathogens_. 2024. Vol. 13, núm. 8, pàgs. 622. [consulta: 7 de febrer de 2026]. ISSN: 2076-0817. [Disponible a: https://hdl.handle.net/2445/219305]

Exportar metadades

JSON - METS

Compartir registre