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2024-04-03

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cc-by (c) Giralt, L. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219885

C-Reactive Protein-Complement Factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

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https://doi.org/10.3389/fimmu.2024.1330913

Resum

Purpose: To determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters. Methods: Cross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters. Results: Patients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels <200 µg/mL were associated with the presence of drusen and pigmentary changes in the fundoscopy (p=0.002). While no differences were observed in pCRP and mCRP levels, and mCRP was only detected in less than 15% of the included participants, women had a significantly higher detection rate of mCRP than men (21.0% vs. 3.8%, p=0.045). In addition, the ratio mCRP/FH (log) was significantly lower in the control group compared to intermediate AMD (p=0.031). Visual acuity (p<0.001), macular volume (p<0.001), and foveal thickness (p=0.034) were significantly lower in the advanced AMD group, and choroidal thickness was significantly lower in advanced AMD compared to early/intermediate AMD (p=0.023). Conclusion: Intermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients.

Matèries

Envelliment, Proteïnes, Malalties de la retina, Marcadors bioquímics, Inflamació

Matèries (anglès)

Aging, Proteins, Retinal diseases, Biochemical markers, Inflammation

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GIRALT, Lena, FIGUERAS ROCA, Marc, DE LUIS EGUILEOR, Beatriz, ROMERO NÚÑEZ, Bárbara, ZARRANZ VENTURA, Javier, ALFORJA, Socorro, SANTIAGO, Francisca, BOLAÑOS, Jennifer, LOZANO, Francisco, DOTTI BOADA, Marina, SALA PUIGDOLLERS, Anna, DURA, Paula, IZQUIERDO SERRA, Jordi, VALERO, Oliver, ADÁN CIVERA, Alfredo, FONOLLOSA, Alex, MOLINS MONTEYS, Blanca. C-Reactive Protein-Complement Factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration. _Frontiers in Immunology_. 2024. Vol. 15. [consulta: 21 de gener de 2026]. ISSN: 1664-3224. [Disponible a: https://hdl.handle.net/2445/219885]

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