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2019-02

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Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia.

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https://doi.org/10.3324/haematol.2018.195032

Resum

Chronic lymphocytic leukemia (CLL) patients with differentialsomatic hypermutation status of the immunoglobulin heavy vari-able genes, namely mutated or unmutated, display fundamentalclinico-biological differences. Considering this, we assessed prognosisseparately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015patients, hypothesizing that the relative significance of relevant indica-tors may differ between these two categories. Within Binet A M-CLLpatients, besides TP53abnormalities, trisomy 12 and stereotyped subset#2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years afterdiagnosis of 40% and 55%, respectively; the remaining cases exhibited5-year and 10-year treatment probability of 12% and 25%, respectively.Within Binet A U-CLL patients, besides TP53abnormalities, del(11q)and/or SF3B1mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respec-tively); in the remaining cases, males had a significantly worse prognosisthan females. In conclusion, the relative weight of indicators that canaccurately risk stratify early-stage CLL patients differs depending on thesomatic hypermutation status of the immunoglobulin heavy variablegenes of each patient. This finding highlights the fact that compartmen-talized approaches based on immunogenetic features are necessary torefine and tailor prognostication in CLL.

Matèries

Leucèmia limfocítica crònica, Pronòstic mèdic

Matèries (anglès)

Chronic lymphocytic leukemia, Prognosis

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Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BALIAKAS, Panagiotis, MOYSIADIS, Theodoros, HADZIDIMITRIOU, Anastasia, XOCHELLI, Aliki, JEROMIN, Sabine, AGATHANGELIDIS, Andreas, MATTSSON, Mattias, SUTTON, Lesley-ann, MINGA, Eva, SCARFÒ, Lydia, ROSSI, Davide, DAVIS, Zadie, VILLAMOR I CASAS, Neus, PARKER, Helen, KOTASKOVA, Jana, STALIKA, Evangelia, PLEVOVA, Karla, MANSOURI, Larry, CORTESE, Diego, NAVARRO LÓPEZ, Alba, DELGADO, Julio (delgado gonzález), LARRAYOZ, Marta, YOUNG, Emma, ANAGNOSTOPOULOS, Achilles, SMEDBY, Karin e., JULIUSSON, Gunnar, SHEEHY, Oonagh, CATHERWOOD, Mark, STREFFORD, Jonathan c., STAVROYIANNI, Niki, BELESSI, Chrysoula, POSPISILOVA, Sarka, OSCIER, David, GAIDANO, Gianluca, CAMPO GÜERRI, Elias, HAFERLACH, Claudia, GHIA, Paolo, ROSENQUIST, Richard, STAMATOPOULOS, Kostas. Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia.. _Haematologica_. 2019. Vol. 104, núm. 2, pàgs. 360-369. [consulta: 24 de gener de 2026]. ISSN: 0390-6078. [Disponible a: https://hdl.handle.net/2445/148044]

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