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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/141217
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis
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Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.
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WELZ, Patrick-Simon, et al. BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis. Cell. 2019. Vol. 177, num. 6, pags. 1436-1447. [consulted: 14 of October of 2026]. Available at: https://hdl.handle.net/2445/141217