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Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.
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Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check-point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.
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POCURULL APARICIO, Anna, et al. Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital. Liver International. 2024. Vol. 44, num. 2, pags. 286-292. ISSN 1478-3223. [consulted: 28 of June of 2026]. Available at: https://hdl.handle.net/2445/227686