Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

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dc.contributor.authorDomingo, Pere (Domingo Pedrol)
dc.contributor.authorGiralt i Oms, Marta
dc.contributor.authorGavaldà i Navarro, Aleix
dc.contributor.authorBlasco Roset, Albert
dc.contributor.authorDelgado Anglés, Alejandro
dc.contributor.authorGallego Escuredo, José Miguel
dc.contributor.authorGutiérrez, Maria del Mar
dc.contributor.authorMateo, Maria Gracia
dc.contributor.authorCereijo Téllez, Rubén
dc.contributor.authorDomingo i Pedrol, Joan Carles
dc.contributor.authorVillarroya i Gombau, Francesc
dc.contributor.authorVillarroya i Terrade, Joan
dc.date.accessioned2025-02-20T19:00:45Z
dc.date.available2025-02-20T19:00:45Z
dc.date.issued2022-12-01
dc.date.updated2025-02-20T19:00:45Z
dc.description.abstractLipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 year-old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that aging of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec720223
dc.identifier.issn2162-3945
dc.identifier.pmidPMID: 35300561
dc.identifier.urihttps://hdl.handle.net/2445/219067
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1080/21623945.2022.2042962
dc.relation.ispartofAdipocyte, 2022, vol. 11, num.1, p. 143-152
dc.relation.urihttps://doi.org/10.1080/21623945.2022.2042962
dc.rightscc-by (c) Domingo, P. et al., 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Bioquímica i Biomedicina Molecular)
dc.subject.classificationSíndrome de lipodistròfia associada a VIH
dc.subject.classificationInflamació
dc.subject.classificationAutofàgia
dc.subject.classificationTeixit adipós
dc.subject.otherHIV-associated lipodystrophy syndrome
dc.subject.otherInflammation
dc.subject.otherAutophagy
dc.subject.otherAdipose tissues
dc.titleAdipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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