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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220530
Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization
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The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vasculariza tion applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4)2+x(SiO4)2-x, which allows several substitutions being Ca7(PO4)2(SiO4)2 the most reported stoichiometry. Inspired by the well-known 45S5 bioactive glass chemical composition, we developed a synthesis route to obtain a Na-rich Nagel single phase. The effect of this bioceramic chemical and structural properties on apatite formation and crystallization mechanism is reported. The structural aspects at the nano and microscale of the mechanism of apatite growth and crystallization from the Nagel phase were compared to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems, revealing a biomimetic behavior during the apatite biomineralization process from the bioceramic.
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ANDREA RINCON-LOPEZ, July, et al. Accelerated bioactive behavior of Nagelschmidtite bioceramics: Mimicking the nano and microstructural aspects of biological mineralization. Journal of the European Ceramic Society. 2021. Vol. 41, num. 15, pags. 7921-7934. ISSN 0955-2219. [consulted: 8 of October of 2026]. Available at: https://hdl.handle.net/2445/220530