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Lenahan_JL_BMJ_Open_Respir_Res_2018.pdf (767.06 KB)

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2018-11

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cc by (c) Lenahan et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/134610

Multicentre pilot study evaluation of lung ultrasound for the management of paediatric pneumonia in low-resource settings: a study protocol

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http://dx.doi.org/ 10.1136/bmjresp-2018-000340

Abstract

Introduction: Pneumonia is the leading infectious cause of death among children under 5 years of age worldwide. However, pneumonia is challenging to diagnose. Lung ultrasound (LUS) is a promising diagnostic technology. Further evidence is needed to better understand the role of LUS as a tool for the diagnosis of childhood pneumonia in low-resource settings. Methods and analysis: This study aims to pilot LUS in Mozambique and Pakistan and to generate evidence regarding the use of LUS as a diagnostic tool for childhood pneumonia. Children with cough <14 days with chest indrawing (n=230) and without chest indrawing (n=40) are enrolled. World Health Organization Integrated Management of Childhood Illness assessment is performed at enrolment, along with a chest radiograph and LUS examination. Respiratory and blood specimens are collected for viral and bacterial testing and biomarker assessment. Enrolled children are followed for 14 days (in person) and 30 days (phone call) post-enrolment with LUS examinations performed on Days 2, 6 and 14. Qualitative and quantitative data are also collected to assess feasibility, usability and acceptability of LUS among healthcare providers and caregivers. The primary outcome is LUS findings at enrolment with secondary outcomes including patient outcomes, repeat LUS findings, viral and bacterial test results, and patient status after 14 and 30 days of follow-up. Ethics and dissemination: This trial was approved by the Western Institutional Review Board as well as local ethics review committees at each site. We plan to disseminate study results in peer-reviewed journals and international conferences.

Subject

Pneumologia pediàtrica, Infància

Subject (English)

Pediatric respiratory diseases, Childhood

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Articles publicats en revistes (ISGlobal)

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LENAHAN, Jennifer L., et al. Multicentre pilot study evaluation of lung ultrasound for the
                management of paediatric pneumonia in low-resource settings: a
                study protocol. BMJ Open Respiratory Medicine. 2018. Vol. 5, num. 1. ISSN 2052-4439. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/134610

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