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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183068
Evaluating the impact of programmatic mass drug administration for malaria in Zambia using routine incidence data.
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BACKGROUND NlmCategory: BACKGROUND content: In
2016, the Zambian National Malaria Elimination Centre started
programmatic mass drug administration (pMDA) campaigns with
dihydroartemisinin-piperaquine as a malaria elimination tool in
Southern Province. Two rounds were administered, two months
apart (coverage 70% and 57% respectively). We evaluated the
impact of one year of pMDA on malaria incidence using routine
data. - Label: METHODS NlmCategory: METHODS content: We
conducted an interrupted time series with comparison group
analysis on monthly incidence data collected at the health
facility catchment area (HFCA) level, with a negative binomial
model using generalized estimating equations. pMDA was conducted
in HFCAs with greater than 50 cases/1,000 people/year. Ten HFCAs
with incidence rates marginally above this threshold (pMDA
group) were compared to 20 HFCAs marginally below (comparison
group). - Label: RESULTS NlmCategory: RESULTS content: "The pMDA
HFCAs saw a 46% greater decrease in incidence at the time of
intervention than the comparison areas (incidence rate ratio:
0.536 [0.337-0.852]); however, incidence increased toward the
end of the season. No HFCAs saw a transmission interruption." -
Label: CONCLUSION NlmCategory: CONCLUSIONS content: pMDA,
implemented during one year with imperfect coverage in low
transmission areas with sub-optimal vector control coverage,
significantly reduced incidence. However, elimination will
require additional tools. Routine data are important resources
for programmatic impact evaluations and should be considered for
future analyses.
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FRASER, Maya, et al. Evaluating the impact of programmatic mass drug administration
for malaria in Zambia using routine incidence data. Journal of Infectious Diseases. 2021. ISSN 0022-1899. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/183068