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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183068
Evaluating the impact of programmatic mass drug administration for malaria in Zambia using routine incidence data.
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BACKGROUND NlmCategory: BACKGROUND content: In
2016, the Zambian National Malaria Elimination Centre started
programmatic mass drug administration (pMDA) campaigns with
dihydroartemisinin-piperaquine as a malaria elimination tool in
Southern Province. Two rounds were administered, two months
apart (coverage 70% and 57% respectively). We evaluated the
impact of one year of pMDA on malaria incidence using routine
data. - Label: METHODS NlmCategory: METHODS content: We
conducted an interrupted time series with comparison group
analysis on monthly incidence data collected at the health
facility catchment area (HFCA) level, with a negative binomial
model using generalized estimating equations. pMDA was conducted
in HFCAs with greater than 50 cases/1,000 people/year. Ten HFCAs
with incidence rates marginally above this threshold (pMDA
group) were compared to 20 HFCAs marginally below (comparison
group). - Label: RESULTS NlmCategory: RESULTS content: "The pMDA
HFCAs saw a 46% greater decrease in incidence at the time of
intervention than the comparison areas (incidence rate ratio:
0.536 [0.337-0.852]); however, incidence increased toward the
end of the season. No HFCAs saw a transmission interruption." -
Label: CONCLUSION NlmCategory: CONCLUSIONS content: pMDA,
implemented during one year with imperfect coverage in low
transmission areas with sub-optimal vector control coverage,
significantly reduced incidence. However, elimination will
require additional tools. Routine data are important resources
for programmatic impact evaluations and should be considered for
future analyses.
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FRASER, Maya, MILLER, John m., SILUMBE, Kafula, HAINSWORTH, Michael, MUDENDA, Mutinta, HAMAINZA, Busiko, MOONGA, Hawela, CHIZEMA KAWESHA, Elizabeth, MERCER, Laina d., BENNETT, Adam, SCHNEIDER, Kammerle, SLATER, Hannah, EISELE, Thomas p., GUINOVART, Caterina. Evaluating the impact of programmatic mass drug administration
for malaria in Zambia using routine incidence data.. _Journal of Infectious Diseases_. 2021. [consulta: 24 de gener de 2026]. ISSN: 0022-1899. [Disponible a: https://hdl.handle.net/2445/183068]