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Bannister-Tyrrell_M_J_Infect_Dis_2019.pdf (10.72 MB)

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2019-04-26

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cc by-nc-nd (c) Bannister-Tyrrell et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/138998

Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia

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http://dx.doi.org/10.1093/infdis/jiz211

Abstract

Background. Malaria “hotspots” have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa. Methods. Clustering of Plasmodium infections at the household and hotspot level was assessed over 2 years in 3 villages in eastern Cambodia. Social and spatial autocorrelation statistics were calculated to assess clustering of malaria risk, and logistic regression was used to assess the effect of living in a malaria hotspot compared to living in a malaria-positive household in the first year of the study on risk of malaria infection in the second year. Results. The crude prevalence of Plasmodium infection was 8.4% in 2016 and 3.6% in 2017. Living in a hotspot in 2016 did not predict Plasmodium risk at the individual or household level in 2017 overall, but living in a Plasmodium-positive household in 2016 strongly predicted living in a Plasmodium-positive household in 2017 (Risk Ratio, 5.00 [95% confidence interval, 2.09–11.96], P < .0001). There was no consistent evidence that malaria risk clustered in groups of socially connected individuals from different households. Conclusions. Malaria risk clustered more clearly in households than in hotspots over 2 years. Household-based strategies should be prioritized in malaria elimination programs in this region.

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Malària, Epidemiologia, Cambodja

Subject (English)

Malaria, Epidemiology, Cambodia

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Articles publicats en revistes (ISGlobal)

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BANNISTER-TYRRELL, Melanie, et al. Households or hotspots? Defining intervention targets for malaria elimination in Ratanakiri Province, eastern Cambodia. Journal of Infectious Diseases. 2019. ISSN 0022-1899. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/138998

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