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Article

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Published version

Publication date

2022-12-01

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cc-by (c) Royo, Romina et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/200343

ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

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Related resource

https://doi.org/10.1038/s41408-022-00686-6

Abstract

Chronic lymphocytic leukemia (CLL) is a disease commonly diagnosed in the elderly with a median age of ~70 years. However, CLL can also be detected in adolescent and young adults (AYA). According to different studies, 0.85-3.7% of patients with CLL are diagnosed in AYA and 3% of these patients had a first-degree relative with CLL. Families with multiple individuals affected with CLL and other related B-cell tumors have been described with contradictory findings regarding their potential early age at diagnosis. Despite these observations, our knowledge about the molecular profile and predisposing factors in AYA CLL is scarce.

Subject

Leucèmia limfocítica crònica, Genòmica, Joves

Subject (English)

Chronic lymphocytic leukemia, Genomics, Youth

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

ROYO, Romina, et al. ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution. Blood Cancer Journal. 2022. Vol. 12, num. 6, pags. 90. ISSN 2044-5385. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/200343

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