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2017-02-27

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cc-by (c) Cortese, Rene et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124205

Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36

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https://doi.org/10.1038/srep43648

Abstract

Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with cardiovascular morbidities. In CIH-exposed mice, closely mimicking the chronicity of human OSA, increased accumulation and proliferation of pro-inflammatory metabolic M1-like macrophages highly expressing CD36, emerged in aorta. Transcriptomic and MeDIP-seq approaches identified activation of pro-atherogenic pathways involving a complex interplay of histone modifications in functionally-relevant biological pathways, such as inflammation and oxidative stress in aorta macrophages. Discontinuation of CIH did not elicit significant improvements in aorta wall macrophage phenotype. However, CIH-induced aorta changes were absent in CD36 knockout mice, Our results provide mechanistic insights showing that CIH exposures during sleep in absence of concurrent pro-atherogenic settings (i.e., genetic propensity or dietary manipulation) lead to the recruitment of CD36(+)high macrophages to the aortic wall and trigger atherogenesis. Furthermore, long-term CIH-induced changes may not be reversible with usual OSA treatment.

Subject

Síndromes d'apnea del son, Oxigen en l'organisme, Obesitat, Inflamació, Morbiditat, Malalties cardiovasculars

Subject (English)

Sleep apnea syndromes, Oxygen in the body, Obesity, Inflammation, Morbidity, Cardiovascular diseases

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Articles publicats en revistes (Biomedicina)

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CORTESE, Rene, et al. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36. Scientific Reports. 2017. Vol. 7, num. 43648. ISSN 2045-2322. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/124205

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