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Data de publicació

2011-07-18

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cc-by (c) Auffarth, Benjamin et al., 2011
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/138057

Statistical analysis of coding for molecular properties in the olfactory bulb

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Recurs relacionat

https://doi.org/10.3389/fnsys.2011.00062

Resum

The relationship between molecular properties of odorants and neural activities is arguably one of the most important issues in olfaction and the rules governing this relationship are still not clear. In the olfactory bulb (OB), glomeruli relay olfactory information to second-order neurons which in turn project to cortical areas. We investigate relevance of odorant properties, spatial localization of glomerular coding sites, and size of coding zones in a dataset of [14C] 2-deoxyglucose images of glomeruli over the entire OB of the rat. We relate molecular properties to activation of glomeruli in the OB using a non-parametric statistical test and a support-vector machine classification study. Our method permits to systematically map the topographic representation of various classes of odorants in the OB. Our results suggest many localized coding sites for particular molecular properties and some molecular properties that could form the basis for a spatial map of olfactory information. We found that alkynes, alkanes, alkenes, and amines affect activation maps very strongly as compared to other properties and that amines, sulfur-containing compounds, and alkynes have small zones and high relevance to activation changes, while aromatics, alkanes, and carboxylics acid recruit very big zones in the dataset. Results suggest a local spatial encoding for molecular properties.

Matèries

Olfacte, Olors

Matèries (anglès)

Smell, Odors

Citació

Col·leccions

Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)

Citació

AUFFARTH, Benjamin, GUTIÉRREZ GÁLVEZ, Agustín and MARCO COLÁS, Santiago. Statistical analysis of coding for molecular properties in the olfactory bulb. Frontiers in systems Neuroscience. 2011. Vol. 5, num. Article 62. ISSN 1662-5137. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/138057

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