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696351.pdf (1.8 MB)

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2020-01-28

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cc-by (c) Bastías-Pérez, Marianela et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/152605

Impact of adaptive thermogenesis in mice on the treatment of obesity

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Recurs relacionat

https://doi.org/10.3390/cells9020316

Resum

Obesity and associated metabolic diseases have become a priority area of study due to the exponential increase in their prevalence and the corresponding health and economic impact. In the last decade, brown adipose tissue has become an attractive target to treat obesity. However, environmental variables such as temperature and the dynamics of energy expenditure could influence brown adipose tissue activity. Currently, most metabolic studies are carried out at a room temperature of 21ºC, which is considered a thermoneutral zone for adult humans. However, in mice this chronic cold temperature triggers an increase in their adaptive thermogenesis. In this review, we aim to cover important aspects related to the adaptation of animals to room temperature, the influence of housing and temperature on the development of metabolic phenotypes in experimental mice and their translation to human physiology. Mice studies performed in chronic cold or thermoneutral conditions allow us to better understand underlying physiological mechanisms for successful, reproducible translation into humans in the fight against obesity and metabolic diseases.

Matèries

Obesitat, Termoregulació, Teixit adipós, Metabolisme basal, Temperatura corporal, Fred

Matèries (anglès)

Obesity, Thermoregulation, Adipose tissues, Basal metabolism, Body temperature, Cold

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

BASTÍAS-PÉREZ, Marianela, et al. Impact of adaptive thermogenesis in mice on the treatment of obesity. Cells. 2020. Vol. 9, num. 316. ISSN 2073-4409. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/152605

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