Cellular S-values for alpha-emitting radionuclides

Abstract

Alpha particles are promising for radiotherapeutic purposes, given their high potency and specificity. This thesis aims to calculate cellular S-values for various source/target combinations across different cell sizes. Monoenergetic He ions and 4 radionuclides that emit alpha particles were considered. S-values were computed based on mass stopping powers from the ICRU Reports 49 and 90, with the objective of analyzing the impact of their variation under different input parameters that influence the final dosimetric outcomes. Also, the energies and yields of the alpha particles emitted in the decay of a few radionuclides of interest were taken from the ICRP Publication 107, which supersedes the older ICRP Publication 38