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2012-10

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cc-by (c) Sánchez Quinto, F. et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/43562

North African populations carry the signature of admixture with Neandertals

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Recurs relacionat

http://dx.doi.org/10.1371/journal.pone.0047765

Resum

One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.

Matèries

ADN, Paleobiologia, Home de Neandertal, Àfrica del Nord, Paleobiologia evolutiva

Matèries (anglès)

DNA, Paleobiology, Neanderthals, Africa, North, Evolutionary paleobiology

Citació

Col·leccions

Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

SÁNCHEZ QUINTO, Federico, RODRÍGUEZ BOTIGUÉ, Laura, CIVIT VIVES, Sergi, ARENAS SOLÀ, Concepción, ÁVILA-ARCOS, María c., BUSTAMANTE, Carlos d., COMAS, David, LALUEZA FOX, Carles. North African populations carry the signature of admixture with Neandertals. _PLoS One_. 2012. Vol. 7, núm. 10, pàgs. e47765. [consulta: 24 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/43562]

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