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2023-10-23

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cc-by-nc-nd (c) Rodríguez et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220699

Synthesis of Alkaloids and Compounds Containing the 3,4-Benzomorphan Scaffold

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https://doi.org/10.1002/ejoc.202300689

Abstract

Several natural products, bearing an embedded hexahydro-2,6-methano-1-benzazocine framework (3,4-benzomorphan) – a heterocyclic regioisomer of the 6,7-benzomorphan substructure found in morphine alkaloids, have therapeutic potential for a variety of diseases. Biogenesis, biosynthetic approaches, and total syntheses of alkaloids or synthetic azapolycyclic compounds featuring the aforementioned azatricyclic ring system (i. e., a 3,4-benzomorphan scaffold) are reviewed.

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Alcaloides, Síntesi orgànica, Ciclització (Química)

Subject (English)

Alkaloids, Organic synthesis, Ring formation (Chemistry)

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

RODRÍGUEZ, Laura G., BONJOCH I SESÉ, Josep and BRADSHAW, Ben. Synthesis of Alkaloids and Compounds Containing the 3,4-Benzomorphan Scaffold. European Journal of Organic Chemistry. 2023. ISSN 1434-193X. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/220699

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