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malerarefreshconsultativepanelontoolsformalariaelimination2017_2858.pdf (1.93 MB)

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2017-11-30

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cc by (c) malERA Refresh Consultative Panel on Tools for Malaria Elimination, 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/119647

malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication

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http://dx.doi.org/10.1371/journal.pmed.1002455

Abstract

Since the turn of the century, a remarkable expansion has been achieved in the range and effectiveness of products and strategies available to prevent, treat, and control malaria, including advances in diagnostics, drugs, vaccines, and vector control. These advances have once again put malaria elimination on the agenda. However, it is clear that even with the means available today, malaria control and elimination pose a formidable challenge in many settings. Thus, currently available resources must be used more effectively, and new products and approaches likely to achieve these goals must be developed. This paper considers tools (both those available and others that may be required) to achieve and maintain malaria elimination. New diagnostics are needed to direct treatment and detect transmission potential; new drugs and vaccines to overcome existing resistance and protect against clinical and severe disease, as well as block transmission and prevent relapses; and new vector control measures to overcome insecticide resistance and more powerfully interrupt transmission. It is also essential that strategies for combining new and existing approaches are developed for different settings to maximise their longevity and effectiveness in areas with continuing transmission and receptivity. For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. This becomes increasingly important as more countries move towards elimination.

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Malària, Malalties parasitàries

Subject (English)

Malaria, Parasitic diseases

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Articles publicats en revistes (ISGlobal)

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malERA Refresh Consultative Panel on Tools for Malaria Elimination and RABINOVICH, Regina. malERA: An updated research agenda for diagnostics, drugs,
                vaccines, and vector control in malaria elimination and
                eradication. PLoS Medicine. 2017. Vol. 14, num. 11, pags. e1002455. ISSN 1549-1277. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/119647

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