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Stereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles

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dc.contributor.authorGhirardi, Elena
dc.contributor.authorGriera Farres, Rosa
dc.contributor.authorPiccichè, Miriam
dc.contributor.authorMolins i Grau, Elies
dc.contributor.authorFernández Cadenas, Israel
dc.contributor.authorBosch Cartes, Joan
dc.contributor.authorAmat Tusón, Mercedes
dc.date.accessioned2017-03-07T14:56:07Z
dc.date.available2017-11-18T23:01:26Z
dc.date.issued2016-11-18
dc.date.updated2017-03-07T14:56:07Z
dc.description.abstractCyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2- oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydroindoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec664992
dc.identifier.issn1523-7060
dc.identifier.pmid27797535
dc.identifier.urihttps://hdl.handle.net/2445/108046
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.6b02861
dc.relation.ispartofOrganic Letters, 2016, vol. 18, num. 22, p. 5836-5839
dc.relation.urihttps://doi.org/10.1021/acs.orglett.6b02861
dc.rights(c) American Chemical Society , 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationLactames
dc.subject.classificationSíntesi asimètrica
dc.subject.otherLactams
dc.subject.otherAsymmetric synthesis
dc.titleStereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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