Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/146287
Intermittent hypoxia is associated with high hypoxia inducible factor-1α but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples. Prospectively recruited patients with CM tumor samples were included and underwent overnight polygraphy. General clinical features, apnea-hypopnea index (AHI), desaturation index (DI4%), and CM characteristics were recorded. Histochemical assessments of VEGF and HIF-1α were performed, and the percentage of positive cells (0, <25, 25-50, 51-75, >75%) was blindly tabulated for VEGF expression, and as 0, 0-5.9, 6.0-10.0, >10.0% for HIF-1α expression, respectively. Cases with HIF-1α expression >6% (high expression) were compared with those <6%, and VEGF expression >75% of cells was compared with those with <75%. 376 patients were included. High expression of VEGF and HIF-1α were seen in 88.8 and 4.2% of samples, respectively. High expression of VEGF was only associated with increasing age. However, high expression of HIF-1α was significantly associated with age, Breslow index, AHI, and DI4%. Logistic regression showed that DI4% [OR 1.03 (95% CI: 1.01-1.06)] and Breslow index [OR 1.28 (95% CI: 1.18-1.46)], but not AHI, remained independently associated with the presence of high HIF-1α expression. Thus, IH emerges as an independent risk factor for higher HIF-1α expression in CM tumors and is inferentially linked to worse clinical CM prognostic indicators.
Matèries
Matèries (anglès)
Citació
Citació
ALMENDROS LÓPEZ, Isaac, MARTÍNEZ GARCÍA, Miguel ángel, CAMPOS RODRÍGUEZ, Francisco, RIVEIRO FALKENBACH, Erica, RODRÍGUEZ PERALTO, José luis, NAGORE, Eduardo, MARTORELL CALATAYUD, Antonio, HERNÁNDEZ BLASCO, Luis, BAÑULS ROCA, Jose, CHINER VIVES, Eusebi, SÁNCHEZ DE LA TORRE, Alicia, ABAD CAPA, Jorge, MONTSERRAT CANAL, José ma., PÉREZ GIL, Amalia, CABRIADA NUÑO, Valentín, CANO PUMAREGA, Irene, CORRAL PEÑAFIEL, Jaime, DIAZ CAMBRILES, Trinidad, MEDIANO, Olga, DALMAU ARIAS, Joan, FARRÉ VENTURA, Ramon, GOZAL, David. Intermittent hypoxia is associated with high hypoxia inducible factor-1α but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients. _Frontiers In Neurology_. 2018. Vol. 9, núm. 272. [consulta: 26 de gener de 2026]. ISSN: 1664-2295. [Disponible a: https://hdl.handle.net/2445/146287]