Fitxers
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Cooperative force generation of KIF1A Brownian motors
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KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.
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ORIOLA SANTANDREU, David and CASADEMUNT I VIADER, Jaume. Cooperative force generation of KIF1A Brownian motors. Physical Review Letters. 2013. Vol. 111, num. 4, pags. 048103. ISSN 0031-9007. [consulted: 23 of June of 2026]. Available at: https://hdl.handle.net/2445/133320