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2020-12-01

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cc-by-nc-nd (c) Fernández et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/175340

Plasma exchange: An efective rescue therapy in critically ill patients with coronavirus disease 2019 infection

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https://doi.org/10.1097/CCM.0000000000004613

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Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can be used as rescue therapy in these patients. Design: Single center case series. Setting: Local study. Subjects: Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions. Interventions: Plasma exchange. Two to six sessions (1.2 plasma volumes). Human albumin (5%) was used as the main replacement fluid. Fresh frozen plasma and immunoglobulins were administered after each session to avoid coagulopathy and hypogammaglobulinemia. Measurements and main results: Serum markers of inflammation and macrophage activation. All patients showed a dramatic reduction in inflammatory markers, including the main cytokines, and improved severity scores after plasma exchange. All survived to ICU admission. Conclusions: Plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection.

Matèries

COVID-19, Plasma sanguini

Matèries (anglès)

COVID-19, Blood plasma

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

FERNÁNDEZ GÓMEZ, Javier, GRATACÓS GINÈS, Jordi, OLIVAS, Pol, COSTA, Montserrat, NIETO, Susana, MATEO ORTEGA, Dolors, SÁNCHEZ RODRÍGUEZ, María belén, AGUILAR, Ferran, BASSEGODA, Octavi, RUIZ, Pablo, CABALLOL, Berta, POCURULL, Anna, LLACH ROCA, Joan, MUSTIELES, M.jesús, CID VIDAL, Joan, REVERTER, Enric, TOAPANTA, David, HERNÁNDEZ TEJERO, María, MARTÍNEZ, José antonio, CLÀRIA I ENRICH, Joan, FERNÁNDEZ, Carlos, MENSA PUEYO, Josep, ARROYO, Vicente, CASTRO, Pedro, LOZANO MOLERO, Miguel. Plasma exchange: An efective rescue therapy in critically ill patients with coronavirus disease 2019 infection. _Critical Care Medicine_. 2020. Vol. 48, núm. 12, pàgs. e1350-e1355. [consulta: 23 de gener de 2026]. ISSN: 0090-3493. [Disponible a: https://hdl.handle.net/2445/175340]

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